Summary
A new study published in Nature Metabolism finds that sucralose, a zero-calorie artificial sweetener sold as Splenda, may increase hunger by altering brain activity.
In a randomized trial of 75 adults, sucralose heightened blood flow to the hypothalamus, associated with appetite, while sucrose reduced it and suppressed hunger.
Sucralose also failed to trigger metabolic hormones like insulin and GLP-1. The effect was stronger in people with obesity.
Researchers warn that artificial sweeteners may disrupt brain signaling and increase cravings, especially in children. Follow-up studies are underway.
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